Čeština
EnglishPyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors
Moravcová, Daniela; Kryštof, Vladimír; Havlíček, Libor; Moravec, Jiří; Lenobel, René; Strnad, Miroslav
BIOORGANIC AND MEDICAL CHEMISTRY LETTERS 13 [18]: 2989-2992, 2003
Keywords: Pyrazolo[4,3-d]pyrimidines; CDK1/cyclin B; anticancer agents
Abstract: A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents.
DOI:
IEB authors: Libor Havlíček, René Lenobel, Miroslav Strnad
BIOORGANIC AND MEDICAL CHEMISTRY LETTERS 13 [18]: 2989-2992, 2003
Keywords: Pyrazolo[4,3-d]pyrimidines; CDK1/cyclin B; anticancer agents
Abstract: A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on cancer cell line K-562, thus may find an application as anticancer agents.
DOI: