Čeština
EnglishEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core
Šíša M., Dvořáková M., Temml V., Jarošová V., Vaněk T., Landa P.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 204 : 112620-112630 , 2020
Klíčová slova: Quinones, Resorcinols, Anti-inflammatory activity, Cyclooxygenase, 5-Lipoxygenase
Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis
Bildziukevich U., Rárová L., Šaman D., Wimmer Z.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 145 : 41-50 , 2018
Klíčová slova:
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases Record contains structures
Vymetalová L., Havlíček L., Šturc A., Skrášková Z., Jorda R., Pospíšil T., Strnad M., Kryštof V.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 110 : 291-301 , 2016
Klíčová slova: Cyclin-dependent kinase Inhibitor Selectivity Bioisostere
Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2.
Kaserer T., Temml V., Kutil Z., Vaněk T., Landa P., Schuster D.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 96 : 445-457 , 2015
Klíčová slova: Method comparison; Docking; Pharmacophore modeling; Shape-based modeling; 2D similarity-based search; Cyclooxygenas
Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin
Kryštof, Vladimír; Moravcová, Daniela; Paprskářová, Martina; Barbier, P.; Peyrot, V.; Hlobilková, Alice; Havlíček, Libor; Strnad, MiroslavEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 41 : 1405-1411 , 2006
Klíčová slova: Myoseverin; Purine; Tubulin